ilac

Research Achievements of iLAC

This is a list of papers where our company is explicitly stated in the author affiliation or Acknowledgements section.
We present research results where our technologies and services were directly utilized.

Publications (English only):

1) Imaizumi A, Adachi Y, Kawaguchi T, Higasa K, Tabara Y, Sonomura K, Sato, T. A., Takahashi M, Mizukoshi T, Yoshida HO, Kageyama N, Okamoto C, Takasu M, Mori M, Noguchi Y, Shimba N, Miyano H, Yamada R, Matsuda F. Genetic basis for plasma amino acid concentrations based on absolute quantification: a genome-wide association study in the Japanese population. Eur J Hum Genet. 2019 Apr;27(4):621-630. doi: 10.1038/s41431-018-0296-y. Epub 2019 Jan 18.Eur J Hum Genet. 2019. PMID: 30659259

2) Kawamura Y, Sanchez Calle A, Yamamoto Y, Sato, T. A., Ochiya T. Extracellular vesicles mediate the horizontal transfer of an active LINE-1 retrotransposon. J Extracell Vesicles. 2019 Jul 23;8(1):1643214. doi: 10.1080/20013078.2019.1643214. eCollection 2019.J Extracell Vesicles. 2019. PMID: 31448067

3) Kakiuchi N, Yoshida K, Uchino M, Kihara T, Akaki K, Inoue Y, Kawada K, Nagayama S, Yokoyama A, Yamamoto S, Matsuura M, Horimatsu T, Hirano T, Goto N, Takeuchi Y, Ochi Y, Shiozawa Y, Kogure Y, Watatani Y, Fujii Y, Kim SK, Kon A, Kataoka K, Yoshizato T, Nakagawa MM, Yoda A, Nanya Y, Makishima H, Shiraishi Y, Chiba K, Tanaka H, Sanada M, Sugihara E, Sato, T. A., Maruyama T, Miyoshi H, Taketo MM, Oishi J, Inagaki R, Ueda Y, Okamoto S, Okajima H, Sakai Y, Sakurai T, Haga H, Hirota S, Ikeuchi H, Nakase H, Marusawa H, Chiba T, Takeuchi O, Miyano S, Seno H, Ogawa S. Frequent mutations that converge on the NFKBIZ pathway in ulcerative colitis. Nature. 2020 Jan;577(7789):260-265. doi: 10.1038/s41586-019-1856-1. PMID: 31853061

4) Brial F, Alzaid F, Sonomura K, Kamatani Y, Meneyrol K, Le Lay A, Péan N, Hedjazi L, Sato, T. A., Venteclef N, Magnan C, Lathrop M, Dumas ME, Matsuda F, Zalloua P, Gauguier D. The Natural Metabolite 4-Cresol Improves Glucose Homeostasis and Enhances β-Cell Function. Cell Rep. 2020 Feb 18;30(7):2306-2320.e5. doi: 10.1016/j.celrep.2020.01.066.Cell Rep. 2020. PMID: 32075738

5) Ochi Y, Kon A, Sakata T, Nakagawa MM, Nakazawa N, Kakuta M, Kataoka K, Koseki H, Nakayama M, Morishita D, Tsuruyama T, Saiki R, Yoda A, Okuda R, Yoshizato T, Yoshida K, Shiozawa Y, Nannya Y, Kotani S, Kogure Y, Kakiuchi N, Nishimura T, Makishima H, Malcovati L, Yokoyama A, Takeuchi K, Sugihara E, Sato, T.A., Sanada M, Takaori-Kondo A, Cazzola M, Kengaku M, Miyano S, Shirahige K, Suzuki HI, Ogawa S. Combined Cohesin-RUNX1 Deficiency Synergistically Perturbs Chromatin Looping and Causes Myelodysplastic Syndromes. Cancer Discov. 2020 Jun;10(6):836-853. doi: 10.1158/2159-8290.CD-19-0982. Epub 2020 Apr 5.Cancer Discov. 2020. PMID: 32249213

6) Tanaka H, Namkoong H, Chubachi S, Irie S, Uwamino Y, Lee H, Azekawa S, Otake S, Nakagawara K, Fukushima T, Watase M, Kusumoto T, Masaki K, Kamata H, Ishii M, Okada Y, Takano T, Imoto S, Koike R, Kimura A, Miyano S, Ogawa S, Kanai T, Sato TA, Fukunaga K; Japan COVID-19 Task Force. Clinical characteristics of patients with COVID-19 harboring detectable intracellular SARS-CoV-2 RNA in peripheral blood cells. Int J Infect Dis. 2023 Oct;135:41-44. doi: 10.1016/j.ijid.2023.07.030. Epub 2023 Aug 3.PMID: 37541421

7) Nasti A, Okumura M, Takeshita Y, Ho TTB, Sakai Y, Sato TA, Nomura C, Goto H, Nakano Y, Urabe T, Nakamura S, Tamura T, Matsubara K, Takamura T, Kaneko S. The declining insulinogenic index correlates with inflammation and metabolic dysregulation in non-obese individuals assessed by blood gene expression. Diabetes Res Clin Pract. 2024 Feb;208:111090. doi: 10.1016/j.diabres.2024.111090. Epub 2024 Jan 11. PMID: 38216088

Papers with Acknowledgments

This research achievement utilizes our company’s technology and services, and our company name is listed in the acknowledgments section of the paper.

Masaki Nakamura MD, Shun-Ichiro Kageyama PhD, Hidenari Hirata PhD, Taku Tochinai BS, Hidehiro Hojo PhD, Atsushi Motegi PhD, Akinori Kanai PhD, Yutaka Suzuki PhD, Katsuya Tsuchihara PhD, Tetsuo Akimoto PhD. Detection of pretreatment circulating tumor DNA predicts recurrence after high-dose proton beam therapy for early-stage non-small cell lung cancer. Int J Radiat Oncol Biol Phys. 2023 Aug 1;116(5):1085-1090. doi: 10.1016/j.ijrobp.2023.02.021. Epub 2023 Feb 22. International Journal of Radiation Oncology, Biology, Physics.
(Acknowledgements: We thank the participating patients and their families. The gene panel used in this study was provided by Illumina, Inc. This study was technically supported by iLAC K.K.)