Next-Generation Sequencing (NGS) is a revolutionary technology for the high-speed, high-volume analysis of nucleic acid sequences.
Leveraging this capability, we offer a wide range of contract sequencing services to meet diverse research and diagnostic needs. Our comprehensive offerings include whole-genome and whole-exome analysis, targeted gene panel sequencing, comprehensive RNA sequencing to measure gene expression, and microbiome analysis to study microbial communities like gut flora.
We comprehensively decode the entire human DNA sequence, which spans approximately 3 billion base pairs.
By combining the latest sequencing technology with advanced data analysis, this method enables high-precision analysis of an individual’s genomic information, including the causes of hereditary diseases, their physical constitution, and drug responsiveness, thereby contributing significantly to both research and clinical applications.
Using next-generation sequencers, this technology efficiently analyzes specific gene panels associated with diseases or physical constitution.
This method allows for the simultaneous detection of numerous genetic mutations with high precision, providing crucial information for both diagnosis and treatment decisions. By focusing on specific gene sets, it significantly reduces the time and cost compared to whole-genome sequencing.
By analyzing circulating tumor DNA (ctDNA) collected from a blood sample, we can gain valuable information for cancer diagnosis, monitoring treatment effectiveness, and the early detection of recurrence.
This non-invasive method provides a significant advantage when obtaining tumor tissue is difficult or when tracking changes over time is necessary, all without putting a burden on the patient.
By examining DNA methylation—a chemical modification where a methyl group is added to a DNA base—this method provides crucial information about gene
expression control.
As an epigenetic change that regulates gene function without
altering the gene sequence, it offers new insights into the mechanisms of cancer
development, disease progression, and various other biological phenomena.
Using next-generation sequencers, transcriptome analysis comprehensively examines the entire set of RNA molecules within a cell (the transcriptome).
This process details changes in gene activation, deactivation, and expression levels under specific conditions, providing essential information for identifying disease-causing genes, evaluating drug responsiveness, and elucidating the mechanisms of vital phenomena like cell differentiation and development.
Spatial analysis enables the high-resolution examination of specific gene and protein expression on tissue sections, preserving crucial spatial information.
Unlike conventional bulk analysis, this method visualizes molecular changes within complex tissue structures and cell-cell interactions, providing new insights into the tumor microenvironment, disease progression mechanisms, and drug action sites.
This technology comprehensively decodes the composition and balance of diverse microbial communities (microbiota) inhabiting specific biological environments such as the oral cavity and intestines using next-generation sequencers.
As it becomes increasingly clear that the interactions between these microorganisms and their hosts are deeply involved in the onset and progression of obesity, diabetes, allergies, autoimmune diseases, and even certain infectious diseases and cancers, they provide crucial information for the development of disease prevention, diagnosis, and treatment methods.
By decoding specific viral sequences with PCR or their entire genomes using next-generation sequencing, we achieve highly accurate identification of viruses and their strains.
This capability is a critical tool for both clinical care and public health, enabling the tracking of mutations to understand transmission, the detection of drug resistance to guide effective treatment, and the provision of essential data for vaccine development and epidemiological investigations.
This technology identifies species inhabiting an environment by collecting and analyzing DNA fragments of biological origin present in soil, water, air, and other environmental samples.
Without capturing or visually observing organisms, it serves as a non-invasive and efficient means of gathering information for ecosystem surveys and conservation, as well as for assessing infectious disease risks. Applications include confirming the presence of endangered species, early detection of invasive species, monitoring biodiversity, and detecting specific pathogens.
Metabolomics and proteomics provide a comprehensive analysis of low-molecular-weight compounds and protein groups using mass spectrometry as a primary tool.
By detailing the types and quantities of these substances, the analysis offers valuable information for understanding life phenomena at the molecular level, including cellular functional states, disease onset mechanisms, drug effects and side effects, and responses to environmental stress. This directly contributes to biomarker discovery and the development of novel therapies.