代表者の研究実績

当社代表がこれまで在籍または兼務してきた大学・研究機関等での研究業績です。
著者所属には当社名は含まれていない論文も含まれていますが、代表者の豊富な研究経験を示すものです。

Publications (English only):

1) Sato, T., Tsunasawa, S., Nakamura, Y., Emi, M., Sakiyama, F., and Matsubara, K.: Expression of the human salivary α-amylase gene in yeast and characterization of the secreted protein. Gene, 50, 247-257, 1986.

2) Nakamura, Y., Sato, T., Emi, M., Miyanohara, A., Nishide, T., and Matsubara, K.: Expression of human salivary α-amylase gene in Saccharomyces cerevisiae and its secretion using the mammalian signal sequence. Gene, 50, 239-245, 1986.

3) Taniguchi, T., Fujita, T., Hatakeyama, M., Mori, H., Matsui, H., Sato, T., Hamuro, J., Minamoto, S., Yamada, G., and Shibuya, H.: Interleukin-2 and its receptor: structure and functional expression of the genes. Cold Spring Harbor Symposia on Quantitative Biology, LI, 577-586, 1986.

4) Sato, T., Matsui, H., Shibahara, S., Kobayashi, T., Morinaga, Y., Kashima, N., Yamasaki, S., Hamuro, J., and Taniguchi, T.: New approach of the high-level expression of human IL-2 cDNA in E. coli. J. Biochem. 101, 525-534, 1987.

5) Morinaga, Y., Takagi, H., Ishida, M., Miwa, K., Sato, T., Nakamori, S., and Sano, K.: Threonine production by co-existence of cloned genes coding homoserine dehydrogenase and homoserine kinase in Brevibacterium lactofermentum. Agric. Biol. Chem., 51, 93-100, 1987.

6) Izumoto, Y., Sato, T., Yamamoto, T., Yoshida, N., Kikuchi, N., Ogawa, M., and Matsubara, K.: Expression of human pancreatic secretory trypsin inhibitor (PSTI) in Saccharomyces cerevisiae. Gene, 59, 151-159, 1987.

7) Sato, T., Uemura, H., Izumoto, Y., Nakao, J., Nakamura, Y., and Matsubara, K.: The conformation of mature α-amylase conditions its secretion from yeast. Gene, 83, 355-365, 1989.

8) Sato, T., Tanigami A., Yamakawa, K., Akiyama, F., Kasumi, F., Sakamoto, G., and Nakamura, Y.: Allelotype of breast cancer: Cumulative allele losses promote tumor progression in primary breast cancer. Cancer Res., 50, 7184-7189, 1990.

9) Yamakawa, K., Takahashi, E., Saito, H., Sato, T., Oshimura, M., Hori, T., and Nakamura, Y.: Isolation and mapping of 75 new DNA markers on human chromosome 3. Genomics, 9, 536-543, 1991.

10) Sato, T., Saito, H., Morita, R., Koi, S., Lee, J.-H., and Nakamura, Y.: Allelotype of human ovarian cancer. Cancer Res., 51, 5118-5122, 1991.

11) Sato, T., Akiyama, F., Sakamoto, G., Kasumi, F., and Nakamura, Y.: Accumulation of genetic alterations and progression of primary breast cancer. Cancer Res., 51, 5794-5799, 1991.

12) Takita, K., Sato, T., Miyagi, M., Watatani, M., Akiyama, F., Sakamoto, G., Kasumi, F., Abe, R., and Nakamura, Y.: Correlation of loss of alleles on the short arms of chromosome 11 and 17 with metastasis of primary breast cancer. Cancer Res., 52, 3914-3917, 1992.

13) Sato, T., Saito, H., Swensen, J., Olifant, A., Wood, C., Danner, D., Sakamoto, T., Takita, K., Kasumi, F., Miki, Y., Skolnick, M., and Nakamura, Y.: The human prohibitin gene located on chromosome 17q21 is mutated in sporadic breast cancer. Cancer Res., 52, 1643-1646, 1992.

14) Bruening, W., Gros, P., Sato, T., Stanimir, J., Nakamura, Y., Housman, D., and Pelletier, J.: Analysis of the 11p13 Wilms’ tumor suppressor gene (WT1) in ovarian tumors. Cancer Investigation, 11, 393-399, 1993.

15) Sato, T., Sakamoto, T., Takita, K., Saito, H., Okui, K., and Nakamura, Y.: The human prohibitin (PHB) gene family and its somatic mutations in human tumors. Genomics, 17, 762-764, 1993.

16) Sakamoto, T., Okamoto, N., Ikeda, Y., Nakamura, Y., and Sato, T.: Dinucleotide repeat polymorphism in DNA of rainbow trout and its application in fisheries science. J. of Fish Biol., 44, 1093-1096, 1994

17) Jones, M. H., Sato, T., Saito, H., Tanigami A., and Nakamura, Y.: Six microsatellite polymorphisms at candidate and confirmed tumor suppressor gene loci. Hum. Mol. Genet., 3: 191, 1994.

18) Sato, T., Irie, S., Krajewski, S., and Reed, J. C.: Cloning and sequencing of cDNA coding rat Bcl-2 protein. Gene, 140, 291-292, 1994.

19) Wang, H.-G., Miyashita, T., Takayama, S., Sato, T., Torigoe, T., Krajewski, S., Tanaka, S., Hovey, L., Troppmair, J., Rapp, U. R., and Reed, J. C.: Apoptosis regulation by interaction of Bcl-2 protein and Raf-1 kinase. Oncogene, 9, 2751-2756, 1994.

20) Sato, T., Hanada, M., Bodrug, S., Irie, S., Iwama, N., Boise, L., Tompson, C., Golemis, E., Fong, L., Wang, H.-G., and Reed, J. C.: Investigation of Bcl-2 protein family interaction using yeast two-hybrid system. Proc. Natl. Acad. Sci. U. S. A. 91, 9238-9242, 1994.

21) Takayama, S., Sato, T., Krajewski, S., Kochel, K., Irie, S., Millan, J., and Reed, J. C.: Cloning and functional analysis of BAG-1: A novel Bcl-2 binding protein with anti-cell death activity. Cell, 80, 279-284, 1995.

22) Sato, T., Irie, S., and Reed, J. C.: A novel member of the TRAF family of putative signal transducing proteins binds to the cytosolic domain of CD40. FEBS lett., 358, 113-118, 1995.

23) Sato, T., Irie, S., Kitada, S., and Reed, J. C.: FAP-1: a protein tyrosine phosphatase that associates with Fas. Science, 268, 411-415, 1995.

24) Fukuda, M. N., Sato, T., Nakayama, J., Klier, G., Mikami, M., Aoki, D., and Nozawa, S.: Trophonin and tastin, a novel cell adhesion molecule complex with potential involvement in embryo implantation. Genes & Dev. 9, 1199-1210, 1995.

25) Hanada, M., Aime-Sempe, C., Sato, T., and Reed, J. C.: Structure-function analysis of Bcl-2 protein: Three conserved domains are important for homodimerization with Bcl-2 and heterodimerization with Bax. J. Biol. Chem., 270, 11962-11969, 1995.

26) Bodrug, S. E., Aime-Sempe, C., Sato, T., Krajewski, S., Hanada, M., and Reed, J. C.: Biochemical and functional comparison of Mcl-1 and Bcl-2 proteins: evidence for a novel mechanism of regulating Bcl-2 family protein function. Cell Death and Differentiation, 2, 173-182, 1995.

27) Inazawa, J., Ariyama, T., Abe, T., Druck, T., Ohta, T., Huebner, K., Yanagisawa, J., Reed, J. C., and Sato, T.: FAP-1, a Fas-associated protein tyrosine phosphatase, is located on the long arm of chromosome 4 at band q21.3.Genomics, 31, 240-242, 1996.

28) Reed, J. C., Miyashita, T., Takayama, S., Wang, H.-G., Sato, T., Krajewski, S., Aime-Sempe, C., Bodrug, S., Kitada, S., and Hanada, M.: Bcl-2 family proteins: Regulators of cell death involved in the pathogenesis of cancer and resistance to therapy. J. Cell. Biochem., 60, 23-32, 1996.

29) Zha, H., Aime-Sempe, C., Sato, T., and Reed, J. C.: Proapoptic protein Bax heterodimerizes with Bcl-2 and homodimerizes with Bax via a novel domain (BH3) distinct from BH1 and BH2. J. Biol. Chem., 271, 7440-7444, 1996.

30) Reed, J. C., Miyashita, T., Krajewski, S., Takayama, S., Aime-Sempe, C., Kitada, S., Sato, T., Wang, H.-G., Harigai, M., Hanada, M., Krajewska, M., Kochel, K., Millan,J., and Kobayashi, H.: Bcl-2 family proteins and the regulation of programmed cell death in leukemia and lymphoma. Molecular Genetics and Therapy of Leukemia, Freireich, E. J. and Kantarjian, H. (eds.), Kluwer Academic Publishers, Boston, 1996.

31) Takayama S., Kochel, K., Irie, S., Inazawa, J., Abe, T., Sato, T., Druck, T., Huebner, K., and Reed, J. C.: Cloning of cDNAs encoding the human BAG1 protein and localization of the human BAG1 gene to chromosome 9p12. Genomics, 35, 494-498, 1996.

32) Sarid, R., Sato, T., Bohenzky, R. A., Russo, J. J., and Chang, Y.: Kaposi’s sarcoma-associated herpesvirus (KSHV) encodes a functional Bcl-2 homolog. Nature Medicine, 3, 293-298, 1997.

33) Yanagisawa, J., Takahashi, M., Kanki, H., Yano-Yanagisawa, H., Sawa, E., Nishitoba, T., Tazunoki, T., Kamishohara, M., Kataoka, S., and Sato, T.: The molecular interaction of Fas and FAP-1: A tripeptide blocker of human Fas with FAP-1 promotes Fas-induced apoptosis. J. Biol. Chem., 272, 8539-8545, 1997.

34) Zhang, X., Brunner, T., Carter, L., Dutton, R. W., Roger, P., Bradley, L., Sato, T., Reed, J. C., Green, D., and Swain, S. L.: Unequal death in Th1 and Th2 effectors: Th1, but not Th2, effectors undergo rapid Fas/FasL-mediated apoptosis. J. Exp. Med., 185, 1837-1849, 1997.

35) Pack, S. D., Tanigami, A., Ledbetter, D. H., Sato, T., and Fukuda, M. N.: Assignment of trophoblast/endometrial epithelium cell adhesion molecule trophinin gene TRO to human chromosome bands Xp11.22–>p11.21 by in situ hybridization. Cytogenet. Cell Genet. 79, 123-124, 1997.

36) Arai, M., Kannagi, M., Matsuoka, M., Sato, T., Yamamoto, N., and Fujii, M.: Expression of FAP-1 (Fas-associated phosphatase) and resistance to Fas-mediated apoptosis in T cell lines derived from human T cell leukemia virus type 1-associated myelopathy/tropical spastic paraparesis patients. AIDS Res. Hum. Retroviruses 14, 261-267, 1998.

37) Suzuki, N., Zara, J., Sato, T., Ong, E., Bakhiet, N., Oshima, R. G., Watson, K. L., and Fukuda, M. N.: A cytoplasmic protein, bystin, interacts with trophinin, tastin, and cytokeratin and may be involved in trophinin-mediated cell adhesion between trophoblast and endometrial epithelial cells. Proc. Natl. Acad. Sci. U. S. A. 95, 5027-5032, 1998.

38) Shao, X., Tandon, R., Samara, G., Kanki, H., Yano, H., Close, L. G., Parsons, R., and Sato, T.: Mutational analysis of the PTEN gene in head and neck squamous cell carcinoma. Int. J. Cancer, 77, 684-688, 1998.

39) Ohyama, T., Li, Y., Utsugi, T., Yamada, Y., and Sato, T.: A dual topoisomerase inhibitor, TAS-103, induces apoptosis in human cancer cells. Jpn. J. Cancer Res. 90, 691-698, 1999.

40) Suzuki, A., Shao, X., Song, X., Hanaoka, T., Irie, S., Kashiwada, M., Samara, G., Close, L. G., Aoki, T., Fujimori, M., Ishikawa, Y., Hatori, M., Hosaka, M., Sakurada, A., Sato, M., Ohuchi, N., Satomi, S., Fukushige, S., Horii, A., and Sato, T.: Identification of a 5-cM region of common allelic loss on 8p12-p21 in human breast cancer and genomic analysis of the hEXT1L/EXTR1/EXTL3 gene in this locus. Int. J. Oncol., 15, 443-451, 1999.

41) Emi M., Yoshimoto, M., Sato, T., Matsumoto, S., Utada, Y., Ito, I., Minobe, K., Iwase, T., Katagiri, T., Bando, K., Akiyama, F., Harada, Y., Fukino, K., Sakamoto, G., Matsushima, M., Iida, A., Tada, T., Saito, H., Miki, Y., Kasumi, F., and Nakamura, Y.: Allelic loss at 1p34, 13q12, 17p13.3, and 17q21.1 correlates with poor postoperative prognosis in breast cancer. Genes, Chromosomes Cancer, 26, 134-141, 1999.

42) Irie, S., Hachiya, T., Rabizadeh, S., Maruyama, W., Mukai, J., Li, Y., Reed J. C., Bredesen, D. E., and Sato, T. A.: Functional interaction of Fas-associated phosphatase-1 (FAP-1) with p75NTR and their effect on NF-κB activation. FEBS Lett., 460, 191-198, 1999.
43) Emi, M., Utada, Y., Yoshimoto, M., Sato, T., Minobe, K., Matsumoto, S., Akiyama, F., Iwase, T., Haga, S., Kajiwara, T., Sakamoto, G., Kasumi, F., and Nakamura, Y.: Correlation of Allelic Loss with Poor Postoperative Survival in Breast Cancer. Breast Cancer, 25, 351-356, 1999.
44) Li, Y., Kanki, H., Hachiya, T., Ohyama, T., Irie, S., Tang, G., Mukai, J., and Sato, T. A.: Attenuation of Fas-induced apoptosis by FAP-1 is involved in Fas-mediated apoptosis as a negative regulator in human T cell leukemia and gastric cancer cell lines. Int. J. Cancer., 87, 473-479, 2000.
45) Mukai, J., Hachiya, T., Hoshino, S., Kimura, M., Nadano, D., Suvanto, P., Hanaoka, T., Li, Y., Irie, S., and Sato, T. A.: NADE, p75NTR-associated cell death executor, is involved in the common neurotrophin receptor p75NTR-mediated signal transduction. J. Biol. Chem., 275, 17566-17570, 2000.

46) Nadano, D. and Sato, T. A.: Caspase-3-dependent and -independent degradation of 28S ribosomal RNA is potentially involved in protein synthesis inhibition in apoptosis initiated by death receptor engagement. J. Biol. Chem., 275, 13967-13973, 2000.

47) Nadano, D., Ishihara, G., Aoki, C., Yoshinaka, T., Irie, S., and Sato, T. A.: Preparation and Characterization of Antibodies against Human Ribosomal Proteins.Heterogeneous Expression of S11 and S30 in a Panel of Human Cancer Cell Lines. Jpn. J. Cancer Res., 91, 802-810, 2000.

48) Maruyama, W., Irie S., and Sato, T. A.: Morphological changes in the nucleus and actin cytoskeleton in the process of Fas-induced apoptosis in Jurkat T cells. Histochemical J., 32, 495-503, 2000.

49) Nakai, Y., Irie, S., and Sato, T. A.: Identification of I kappa B alpha as a substrate of Fas-associated phosphatase-1. Eur. J. Biochem., 267, 7170-7175, 2000.

50) Park J. A., Lee J.-Y., Sato, T. A., and Koh. J.-Y.: Co-Induction of p75NTR and p75NTR-Associated Death Executor in Neurons after Zinc Exposure in Cortical Culture or Transient Ischemia in the Rat. J. Neurosci., 20, 9096-9103, 2000.

51) Okamoto-Hosoya, Y., Sato, T. A., and Ochi, K.: Resistance to paromomycin is conferred by rpsL mutations, accompanied by an enhanced antibiotic production in Streptomyces coelicolor A3(2). J. Antibiot (Tokyo), 53, 1424-1427, 2000.

52) Hanaoka, T., Nakayama, J., Mukai, J., Irie, S., Amanda, T., and Sato, T. A.: Association of smoking with apoptosis-regulated proteins (Bcl-2, Bax and p53) in resected non-small-cell lung cancers. Int. J. Cancer, 91, 267-269, 2001.

53) Sano, H., Mukai, J., Monoo, K., Close, L. G., and Sato, T. A.: Expression of p75NTR and its associated protein NADE in the rat cochlea. Laryngoscope, 111, 535-538, 2001.

54) Mizuno, K., Shao, X., Irie, S., and Sato, T. A.: Overexpression of EXTL3/EXTR1 enhances NF-κB activity induced by TNFα. Cellular Sig., 13, 125-130, 2001.

55) Kimura, M. T., Irie, S., Hoshino, S., Mukai, J., Nadano, D., Oshimura, M., and Sato, T. A.: 14-3-3 is involved in p75NTR-mediated signal transduction. J. Biol. Chem., 276: 17291-17300, 2001.

56) Irie, S., Li, Y., Kanki, H., Ohyama, T., Deaven, L. L., Somlo, S., and Sato, T. A.: Identification of two Fas-associated phosphatase-1 (FAP-1) promoters in human cancer cells. DNA seq., 11: 519-526, 2001.

57) Nadano, D., Aoki, C., Yoshinaka, T., Irie, S., and Sato, T. A.: Electrophoretic characterization of ribosomal subunits and proteins in apoptosis: specific down-regulation of S11 in staurosporine-treated human breast carcinoma cells. Biochemistry, 40: 15184-15193, 2001.

58) Mukai, J., Shoji, S., Kimura, M.T., Okubo, S., Sano, H., Suvanto, P., Li, Y., Irie, S., and Sato, T. A.: Structure-function analysis of NADE: Identification of regions that mediate NGF-induced Apoptosis. J. Biol. Chem., 277: 13973-13982, 2002.

59) Nishida, J., Shiratsuchi, A., Nadano, D., Sato, T. A., and Nakanishi, Y.: Structural change of ribosomes during apoptosis: degradation and translocation of ribosomal proteins in apoptotic cells. J. Biochem., 131, 485-943, 2002.

60) Nadano, D., Nakayama, J., Matsuzawa, S.-I., Sato, T. A., Matsuda, T., and Fukuda, M. N.: Human tastin, a proline-rich cytoplasmic protein, associates with the microtubular cytoskeleton. Biochem. J., 364, 669-677, 2002.

61) Brogna, S., Sato, T. A., and Rosbash, M.: Ribosomes are associated with sites of transcription. Mol. Cell, 10, 93-104, 2002.

62) Hanaoka, T., Nakayama, J., Haniuda, M., and Sato, T. A.: Immunohistochemical demonstration of apoptosis-regulated proteins, Bcl-2 and Bax, in resected non-small-cell lung cancers. Int. J. Clin. Oncol., 7, 152-158, 2002.

63) Nadano, D., Notsu, T., Matsuda, T., and Sato, T. A.: A human gene encoding a protein homologous to ribosomal protein L39 is normally expressed in the testis and its expression suppressed in multiple cancer cells. Biochim. Biophys. Acta,, 1577, 430-436, 2002.

64) Ohashi, S., koike, K., Omori, A., Ichinose, S., Ohara, S., Kobayashi, S., Sato, T. A., and Anzai, K.: Identification of mRNP complexes containing Pur alpha, mStaufen, Fragile X protein and Myosin Va, and their association with rough endoplasmic reticulum equipped with a kinesin motor. J. Biol. Chem., 277, 37804-37810, 2002.

65) Kasai, H., Nadano, D., Hidaka, E., Higuchi, K., Kawakubo, M., Sato, T. A., and Nakayama, J.: Differential Expression of Ribosomal Proteins in Human Normal and Neoplastic Colorectum
J. Histochem. Cytochem., 51, 567-574, 2003.

66) Shimizu, S., Ishida, K., Wierzba, M. K., Sato, T. A., and Osada, H.: Expression of heparanase in human tumor cell lines and human head and neck tumors. Cancer Lett., 193, 83-89, 2003.

67) Ivanov, V. N., Bergami, P. L., Maulit, G., Sato, T. A., Sasson, D., and Ronai, Z: FAP-1 association with Fas (APO-1) inhibits Fas expression on the cell surface. Mol. Cell. Biol., 23, 3623-3635, 2003.

68) Yi, J.-S., Lee, S.-K., Sato, T. A., and Koh, J.-Y.: Co-induction of p75NTR and the associated death executor NADE in degenerating hippocampal neurons after kainate-induced seizures in the rat. Neurosci. Lett., 347, 126-130, 2003.

69) Mukai, J., Suvanto, P., and Sato, T. A.: NGF-dependent regulation of NADE-induced apoptosis, Vitam. Horm., 66, 385-402, 2003.

70) Funakoshi, T., Kobayashi, S., Ohashi, S., Sato, T. A., and Anzai, K.: Isolation and characterization of brain Y-box protein: developmentally regulated expression, polyribosomal association and dendritic localization. Brain Res. Mol. Brain Res., 118, 1-9, 2003.

71) Kim, S., Ulz, M. E., Nguyen, T., Li, C.-M., Sato, T. A., Tycko, B., and Ju, J.: Thirtyfold multiplex genotyping of the p53 gene using solid phase capturable dideoxynucleotides and mass spectrometry. Genomics., 83, 924-931, 2004.

72) Miyazaki T., Atarashi, Y., Yasumura, S., Minatoya, I., Ogawa, K., Iwamoto, M., Minemura, M., Shimizu, Y., Sato, T. A., Watanabe, A., and Sugiyama, T.: Fas-associated phosphatase-1 promote Fas-mediated apoptosis in human colon cancer cells: Novel function of FAP-1. J. Gastroenterol. Hepatol., 1, 84-91, 2006.

73) Wieckowski, E., Atarashi, Y., Stanson, J., Sato, T. A., and Whiteside, T. L.: FAP-1-mediated activation of NF-kappaB induces resistance of head and neck cancer to fas-induced apoptosis. J. Cell. Biochem., 100, 16-28, 2007.

74) Mamane, Y., Petroulakis, E., Martineau, Y., Sato, T. A., Larsson, O., Rajasekhar, V. K., and Sonenberg, N.: Epigenetic activation of a subset of mRNAs by eIF4E explains its effects on cell proliferation. PLoS ONE. e242, Feb 21, 2007

75) Ueda, K., Katagiri, T., Shimada, T., Irie, S., Sato, T. A., Nakamura, Y., and Daigo. Y.: Comparative profiling of serum glycoproteome by sequential purification of glycoproteins and 2-nitrobenzensulfenyl (NBS) stable isotope labeling: a new approach for the novel biomarker discovery for cancer. J Proteome Res., 9, 3475-83, 2007.

76) Aoki, Y., Toyama, A., Shimada, T., Sugita, T., Aoki, C., Umino, Y., Suzukki, A., Aoki, D., Daigo, Y., Nakamura, Y., and Sato, T. A.: A novel method for analyzing formalin-fixed paraffin embedded (FFPE) tissue sections by mass spectrometry imaging. Proc. Jpn. Acad., Ser. B 83, 205-214, 2007.

77) Yokoo, S., Yamagami, S., Shimada, T., Usui, T., Sato, T. A., Amano, S., Araie, N., and Hamuro, J.: A novel isolation technique of progenitor cells in human corneal epithelium using non-tissue culture dishes. Stem Cells. 26, 1743-1748, 2008.

78) Ueda, K., Fukase, Y., Katagiri, T., Ishikawa, N., Irie, S., Sato, T. A., Ito, H., Nakayama, H., Miyagi, Y., Tsuchiya, E., Kohno, N., Shiwa, M., Nakamura, Y., and Daigo, Y.: Targeted serum glycoproteomics for the discovery of lung cancer-associated glycosylation disorders using lectin-coupled ProteinChip arrays. Proteomics. Apr; 9(8), 2182-2192, 2009.

79) Hiraishi, H., Shimada, T., Otsu I., Sato, T. A., and Takagi, H.: The yeast ubiquitin ligase Rsp5 down-regulates the alpha subunit of nascent polypeptide-associated complex Egd2 under stress conditions. FEBS J., 276, 5287-5297, 2009.

80) Ueda, K., Takami, S., Saichi, N., Daigo, Y., Ishikawa, N., Kohno, N., Katsumata, M., Yamane, A., Ota, M., Sato, T. A., Nakamura, Y., and Nakagawa, H.: Development of serum glycoproteomic profiling technique; simultaneous identification of glycosylation sites and site-specific quantification of glycan structure changes. Mol Cell Proteomics. 9, 1819-1828, 2010.

81) Shimada, T., Nakanishi, T., Toyama, A., Yamauchi, S., Kanzaki, A., Fujiwake, H., Sato, T. A., and Ikegawa, M.: Potential implications for monitoring serum bile acid profiles in circulation with serum proteome for carbon tetrachloride-induced liver injury / regeneration model in mice. J. Proteome Res. 9, 4490-4500, 2010.

82) Toyama, A., Nakagawa, H., Matsuda, K., Ishikawa, N., Kohno, N., Daigo, Y., Sato, T. A., Nakamura, Y., and Ueda, K.: Deglycosylation and label-free quantitative LC-MALDI MS applied to efficient serum biomarker discovery of lung cancer. Proteome Sci. 9, Apr 8, 2011.

83) Ueda, K., Saichi, N., Takami, S., Kang, D., Toyama, A., Daigo, Y., Ishikawa, N., Kohno, N., Tamura, K., Shuin, T., Nakayama, M., Sato, T. A., Nakamura, Y., and Nakagawa, H..: A comprehensive peptidome profiling technology for the identification of early detection biomarkers for lung adenocarcinoma. PLoS One. 6, Apr 11, 2011.
84) Capon, D. J., Kaneko, N., Yoshimori, T., Shimada, T., Wurm, F. M., Hwang, P. K., Tong, X., Adams, S. A., Simmons, G., Sato, T. A., and Tanaka, K.: Flexible antibodies with nonprotein hinges. Proc Jpn Acad Ser B Phys Biol Sci. 87(9):603-16, 2011.
85) Shimada, T., Toyama, A., Aoki, C., Aoki, Y., Tanaka, K., and Sato, T. A.: Direct antigen detection from immunoprecipitated beads using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry; a new method for immunobeads-mass spectrometry (iMS). Rapid Commun Mass Spectrom. 25(23):3521-6, 2011.
86) Sebbag-Sznajder, N., Raitskin, O., Angenitzki, M., Sato, T. A., Sperling, J., and Sperling, R.: Regulation of alternative splicing within the supraspliceosome. J. Struct Biol. 177(1):152-9, 2012.

87) Shimada, T., Kuyama, H., Sato, T. A. and Tanaka, K.: Development of iodoacetic acid-based cysteine mass tags: Detection enhancement for cysteine-containing peptide by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Anal Biochem. Epub. 2012
88) Toyama, A., Suzuki, A., Shimada, T., Aoki, C., Aoki, Y., Umino, Y., Nakamura, Y., Aoki, D. and Sato. T. A.: Proteomic characterization of ovarian cancers identifying annexin-A4, phosphoserine aminotransferase, cellular retinoic acid-binding protein 2, and serpin B5 as histology-specific biomarkers. Cancer Sci., 103, 747-755, 2012.
89) Hatakeyama, K., Wakabayashi-Nakao, K., Aoki, Y., Ogura, S. I., Yamaguchi, K., Nakajima, T., Sato, T. A., Mochizuki, T. and Hayashi, I.: Novel protein extraction approach using micro-sized chamber for evaluation of proteins eluted from formalin-fixed paraffin-embedded tissue sections. Proteome Sci., 10(1):19. 10, 2012.
90) Kaneshiro, K., Watanabe, M., Terasawa, K., Uchimura, H., Fukuyama, Y., Iwamoto, S., Sato, T. A., Shimizu, K., Tsujimoto, G. and Tanaka, K.: Rapid quantitative profiling of N-glycan by the glycan-labeling method using 3-aminoquinoline/α-cyano-4-hydroxycinnamic acid. Anal Chem., 84, 7146-7151, 2012.

91) Toyama, A., Nakagawa, H., Matsuda, K., Sato, T. A., Nakamura, Y. and Ueda, K.:
Quantitative structural characterization of local N-glycan microheterogeneity in therapeutic antibodies by energy-resolved oxonium ion monitoring. Anal Chem., 84, 9655-9662, 2012.

92) Watanabe, M., Terasawa, K., Kaneshiro, K., Uchimura, H., Yamamoto, R., Fukuyama, Y., Shimizu, K., Sato, T. A. and Tanaka, K.: Improvement of mass spectrometry analysis of glycoproteins by MALDI-MS using 3-aminoquinoline/α-cyano-4-hydroxycinnamic acid. Anal Bioanal Chem., 405, 4289-4293, 2013.

93) Kaneko, N., Yoshimori, T., Yamamoto, R., Capon, D. J., Shimada, T., Sato, T. A. and Tanaka, K.: Multi epitope-targeting immunoprecipitation using F(ab’) fragments with high affinity and specificity for the enhanced detection of a peptide with matrix-assisted laser desorption ionization-time-of-flight mass spectrometry. Anal Chem., 85, 3152-3159, 2013.

94) Kawashima, M., Iwamoto, N., Kawaguchi-Sakita, N., Sugimoto, M., Ueno, T., Mikami, Y., Terasawa, K., Sato, T. A., Tanaka, K., Shimizu, K. and Toi, M.: High-resolution imaging mass spectrometry reveals detailed spatial distribution of phosphatidylinositols in human breast cancer. Cancer Sci., 104, 1372-1379, 2013.

95) Ito, E., Nakajima, K., Waki, H., Miseki, K., Shimada, T., Sato, T. A., Kakehi, K., Suzuki, M., Taniguchi, N. and Suzuki, A.: Structural characterization of pyridylaminated oligosaccharides derived from neutral glycosphingolipids by high-sensitivity capillary electrophoresis-mass spectrometry. Anal Chem., 85, 7859-7865, 2013.

96) Ito, E., Waki, H., Miseki, K., Shimada, T., Sato, T. A., Kakehi, K., Suzuki, M. and Suzuki, A.: Structural characterization of neutral glycosphingolipids using high-performance liquid chromatography-electrospray ionization mass spectrometry with a repeated high-speed polarity and MSn switching system. Glycoconj J., 85, 7859-7865, 2013.

97) Ueda, K., Tatsuguchi, A., Saichi, N., Toyama, A., Tamura, K., Furihata, M., Takata, R., Akamatsu, S., Igarashi, M., Nakayama, M., Sato, T. A., Ogawa, O., Fujioka, T., Shuin, T., Nakamura, Y. and Nakagawa. H.: Plasma Low-Molecular-Weight Proteome Profiling Identified Neuropeptide-Y as a Prostate Cancer Biomarker Polypeptide. J Proteome Res., 12, 4497-4506, 2013.

98) Iwamoto, N., Shimada, T., Umino, Y., Aoki, C., Aoki, Y., Sato, T. A., Hamada, A. and Nakagama, H.: Selective detection of complementarity-determining regions of monoclonal antibody by limiting protease access to the substrate: nano-surface and molecular-orientation limited proteolysis. Analyst. 139, 576-580, 2014.

99) Kaneko, N., Yamamoto, R., Sato, T. A. and Tanaka, K.: Identification and quantification of amyloid beta-related peptides in human plasma using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Proc Jpn Acad Ser B Phys Biol Sci., 90, 104-117, 2014.

100) Sonomura, K., Kudoh, S., Sato, T. A. and Matsuda, F.: Plasma lipid analysis by hydrophilic interaction liquid chromatography coupled with electrospray ionization tandem mass spectrometry. J Sep Sci., 38, 2033-2037, 2015.

101) Kawamura, Y., Yamamoto, Y., Sato, T. A. and Ochiya, T.: Extracellular vesicles as trans-genomics agents: Emerging roles in disease and evolution. Cancer Sci., 108, 824-830, 2017.
102) Rodriguez-Martinez, A., Posma, J. M., Ayala, R., Harvey, N., Jimenez, B., Neves, A. L., Lindon, J. C., Sonomura, K., Sato, T. A. , Matsuda, F., Zalloua, P., Gauguier, D., Nicholson, J. K., and Dumas, M. E.: J-Resolved 1H NMR 1D-Projections for Large-Scale Metabolic Phenotyping Studies: Application to Blood Plasma Analysis. Anal Chem., 89, 11405-11412, 2017.

103) Imaizumi A, Adachi Y, Kawaguchi T, Higasa K, Tabara Y, Sonomura K, Sato, T. A., Takahashi M, Mizukoshi T, Yoshida HO, Kageyama N, Okamoto C, Takasu M, Mori M, Noguchi Y, Shimba N, Miyano H, Yamada R, Matsuda F. Genetic basis for plasma amino acid concentrations based on absolute quantification: a genome-wide association study in the Japanese population. Eur J Hum Genet. 2019 Apr;27(4):621-630. doi: 10.1038/s41431-018-0296-y. Epub 2019 Jan 18.Eur J Hum Genet. 2019. PMID: 30659259

104) Kawamura Y, Sanchez Calle A, Yamamoto Y, Sato, T. A., Ochiya T. Extracellular vesicles mediate the horizontal transfer of an active LINE-1 retrotransposon. J Extracell Vesicles. 2019 Jul 23;8(1):1643214. doi: 10.1080/20013078.2019.1643214. eCollection 2019.J Extracell Vesicles. 2019. PMID: 31448067

105) Kakiuchi N, Yoshida K, Uchino M, Kihara T, Akaki K, Inoue Y, Kawada K, Nagayama S, Yokoyama A, Yamamoto S, Matsuura M, Horimatsu T, Hirano T, Goto N, Takeuchi Y, Ochi Y, Shiozawa Y, Kogure Y, Watatani Y, Fujii Y, Kim SK, Kon A, Kataoka K, Yoshizato T, Nakagawa MM, Yoda A, Nanya Y, Makishima H, Shiraishi Y, Chiba K, Tanaka H, Sanada M, Sugihara E, Sato, T. A., Maruyama T, Miyoshi H, Taketo MM, Oishi J, Inagaki R, Ueda Y, Okamoto S, Okajima H, Sakai Y, Sakurai T, Haga H, Hirota S, Ikeuchi H, Nakase H, Marusawa H, Chiba T, Takeuchi O, Miyano S, Seno H, Ogawa S. Frequent mutations that converge on the NFKBIZ pathway in ulcerative colitis. Nature. 2020 Jan;577(7789):260-265. doi: 10.1038/s41586-019-1856-1. PMID: 31853061

106) Brial F, Alzaid F, Sonomura K, Kamatani Y, Meneyrol K, Le Lay A, Péan N, Hedjazi L, Sato, T. A., Venteclef N, Magnan C, Lathrop M, Dumas ME, Matsuda F, Zalloua P, Gauguier D. The Natural Metabolite 4-Cresol Improves Glucose Homeostasis and Enhances β-Cell Function. Cell Rep. 2020 Feb 18;30(7):2306-2320.e5. doi: 10.1016/j.celrep.2020.01.066.Cell Rep. 2020. PMID: 32075738

107) Ochi Y, Kon A, Sakata T, Nakagawa MM, Nakazawa N, Kakuta M, Kataoka K, Koseki H, Nakayama M, Morishita D, Tsuruyama T, Saiki R, Yoda A, Okuda R, Yoshizato T, Yoshida K, Shiozawa Y, Nannya Y, Kotani S, Kogure Y, Kakiuchi N, Nishimura T, Makishima H, Malcovati L, Yokoyama A, Takeuchi K, Sugihara E, Sato, T. A., Sanada M, Takaori-Kondo A, Cazzola M, Kengaku M, Miyano S, Shirahige K, Suzuki HI, Ogawa S. Combined Cohesin-RUNX1 Deficiency Synergistically Perturbs Chromatin Looping and Causes Myelodysplastic Syndromes. Cancer Discov. 2020 Jun;10(6):836-853. doi: 10.1158/2159-8290.CD-19-0982. Epub 2020 Apr 5.Cancer Discov. 2020. PMID: 32249213

108) Sugihara E, Hashimoto N, Osuka S, Shimizu T, Ueno S, Okazaki S, Yaguchi T, Kawakami Y, Kosaki K, Sato, T. A., Okamoto S, Saya H. The Inhibitor of Apoptosis Protein Livin Confers Resistance to Fas-Mediated Immune Cytotoxicity in Refractory Lymphoma. Cancer Res. 2020 Oct 15;80(20):4439-4450. doi: 10.1158/0008-5472.CAN-19-3993. Epub 2020 Sep 14.Cancer Res. 2020. PMID: 32928920

109) Koyanagi I, Sonomura K, Naoi T, Ohnishi T, Kaneko N, Sawamoto K, Sato, T. A., Sakaguchi M. Metabolic fingerprints of fear memory consolidation during sleep. Mol Brain. 2021 Feb 10;14(1):30. doi: 10.1186/s13041-021-00733-6.Mol Brain. 2021. PMID: 33568175

110) Shiga M, Miyazaki J, Tanuma K, Nagumo Y, Yoshino T, Kandori S, Negoro H, Kojima T, Tanaka R, Okiyama N, Fujisawa Y, Watanabe M, Yamasaki S, Kiyohara H, Watanabe M, Sato, T. A., Tahara H, Nishiyama H, Yano I. The liposome of trehalose dimycolate extracted from M. bovis BCG induces antitumor immunity via the activation of dendritic cells and CD8+ T cells. Cancer Immunol Immunother. 2021 Feb 11. doi: 10.1007/s00262-021-02870-2. 2021. PMID: 33570675

111) Fujii Y, Sato Y, Suzuki H, Kakiuchi N, Yoshizato T, Lenis AT, Maekawa S, Yokoyama A, Takeuchi Y, Inoue Y, Ochi Y, Shiozawa Y, Aoki K, Yoshida K, Kataoka K, Nakagawa MM, Nannya Y, Makishima H, Miyakawa J, Kawai T, Morikawa T, Shiraishi Y, Chiba K, Tanaka H, Nagae G, Sanada M, Sugihara E, Sato, T. A., Nakagawa T, Fukayama M, Ushiku T, Aburatani H, Miyano S, Coleman JA, Homma Y, Solit DB, Kume H, Ogawa S. Molecular classification and diagnostics of upper urinary tract urothelial carcinoma. Cancer Cell. 2021 Jun 14;39(6):793-809.e8. doi: 10.1016/j.ccell.2021.05.008.Cancer Cell. 2021. PMID: 34129823

112) Borisova E, Nishimura K, An Y, Takami M, Li J, Song D, Matsuo-Takasaki M, Luijkx D, Aizawa S, Kuno A, Sugihara E, Sato TA, Yumoto F, Terada T, Hisatake K, Hayashi Y. Structurally-discovered KLF4 variants accelerate and stabilize reprogramming to pluripotency. iScience. 2021 Dec 14;25(1):103525. doi: 10.1016/j.isci.2021.103525. eCollection 2022 Jan 21. PMID: 35106457

113) Aizawa S, Nishimura K, Mondejar GS, Kumar A, Bui PL, Tran YTH, Kuno A, Muratani M, Kobayashi S, Nabekura T, Shibuya A, Sugihara E, Sato TA, Fukuda A, Hayashi Y, Hisatake K. Early reactivation of clustered genes on the inactive X chromosome during somatic cell reprogramming. Stem Cell Reports. 2022 Jan 11;17(1):53-67. doi: 10.1016/j.stemcr.2021.11.008. Epub 2021 Dec 16.PMID: 34919813

114) Tanaka K, Kandori S, Sakka S, Nitta S, Tanuma K, Shiga M, Nagumo Y, Negoro H, Kojima T, Mathis BJ, Shimazui T, Watanabe M, Sato TA, Miyamoto T, Matsuzaka T, Shimano H, Nishiyama H ELOVL2 promotes cancer progression by inhibiting cell apoptosis in renal cell carcinoma. Oncol Rep. 2022 Feb;47(2):23. doi: 10.3892/or.2021.8234. Epub 2021 Nov 29.PMID: 34841437

115) Suzuki-Abe H, Sonomura K, Nakata S, Miyanishi K, Mahmoud A, Hotta-Hirashima N, Miyoshi C, Sato TA, Funato H, Yanagisawa M. Metabolomic and pharmacologic analyses of brain substances associated with sleep pressure in mice. Neurosci Res. 2022 Apr;177:16-24. doi: 10.1016/j.neures.2021.11.008. Epub 2021 Nov 29.　PMID: 34856199

116) Anh LPH, Nishimura K, Kuno A, Linh NT, Kato T, Ohtaka M, Nakanishi M, Sugihara E, Sato TA, Hayashi Y, Fukuda A, Hisatake K. Downregulation of Odd-Skipped Related 2, a Novel Regulator of Epithelial-Mesenchymal Transition, Enables Efficient Somatic Cell Reprogramming.. Stem Cells. 2022 Apr 29;40(4):397-410. doi: 10.1093/stmcls/sxac012.PMID: 35385105

117) Shichino S, Ueha S, Hashimoto S, Ogawa T, Aoki H, Wu B, Chen CY, Kitabatake M, Ouji-Sageshima N, Sawabata N, Kawaguchi T, Okayama T, Sugihara E, Hontsu S, Ito T, Iwata Y, Wada T, Ikeo K, Sato TA, Matsushima K. TAS-Seq is a robust and sensitive amplification method for bead-based scRNA-seq. Commun Biol. 2022 Jun 27;5(1):602. doi: 10.1038/s42003-022-03536-0.PMID: 35760847

118) Iwasaki T, Kamatani Y, Sonomura K, Kawaguchi S, Kawaguchi T, Takahashi M, Ohmura K, Sato TA, Matsuda F. Genetic influences on human blood metabolites in the Japanese population. iScience. 2022 Dec 6;26(1):105738. doi: 10.1016/j.isci.2022.105738. eCollection 2023 Jan 20. PMID: 36582826

119) Tanaka H, Namkoong H, Chubachi S, Irie S, Uwamino Y, Lee H, Azekawa S, Otake S, Nakagawara K, Fukushima T, Watase M, Kusumoto T, Masaki K, Kamata H, Ishii M, Okada Y, Takano T, Imoto S, Koike R, Kimura A, Miyano S, Ogawa S, Kanai T, Sato TA, Fukunaga K; Japan COVID-19 Task Force. Clinical characteristics of patients with COVID-19 harboring detectable intracellular SARS-CoV-2 RNA in peripheral blood cells. Int J Infect Dis. 2023 Oct;135:41-44. doi: 10.1016/j.ijid.2023.07.030. Epub 2023 Aug 3.PMID: 37541421

120) Nakatsuka Y, Murase K, Sonomura K, Tabara Y, Nagasaki T, Hamada S, Matsumoto T, Minami T, Kanai O, Takeyama H, Sunadome H, Takahashi N, Nakamoto I, Tanizawa K, Handa T, Sato TA, Komenami N, Wakamura T, Morita S, Takeuchi O, Nakayama T, Hirai T, Kamatani Y, Matsuda F, Chin K. Hyperfructosemia in sleep disordered breathing: metabolome analysis of Nagahama study. Sci Rep. 2023 Aug 5;13(1):12735. doi: 10.1038/s41598-023-40002-1.PMID: 37543666

121) Liu L, Kawashima M, Sugimoto M, Sonomura K, Pu F, Li W, Takeda M, Goto T, Kawaguchi K, Sato TA, Toi M. Discovery of lipid profiles in plasma-derived extracellular vesicles as biomarkers for breast cancer diagnosis. Cancer Sci. 2023 Oct;114(10):4020-4031. doi: 10.1111/cas.15935. Epub 2023 Aug 22. PMID: 37608343

122) Hara T, Kazuno AA, Toyota T, Ueda J, Shuno T, Mukai J, Sato TA, Matsumoto N, Yoshikawa T, Takata A. A case of bipolar I disorder with a loss-of-function variant of schizophrenia risk gene SETD1A: possible expansion of the relevant clinical spectrum supported by a meta-analysis. Psychiatry Clin Neurosci. 2024 Jun;78(6):374-375. doi: 10.1111/pcn.13669. Epub 2024 Apr 22. PMID: 38646907

123) Nasti A, Okumura M, Takeshita Y, Ho TTB, Sakai Y, Sato TA, Nomura C, Goto H, Nakano Y, Urabe T, Nakamura S, Tamura T, Matsubara K, Takamura T, Kaneko S. The declining insulinogenic index correlates with inflammation and metabolic dysregulation in non-obese individuals assessed by blood gene expression. Diabetes Res Clin Pract. 2024 Feb;208:111090. doi: 10.1016/j.diabres.2024.111090. Epub 2024 Jan 11. PMID: 38216088

124) Yoshimura T, Kamatani T, Ookubo A, Takahashi M, Itoh M, Ebisudani T, Masugi Y, Toyonaga T, Hamamoto J, Saotome K, Sakai K, Yoshihama T, Moritoki N, Shibata S, Yasuda H, Sato T, Sato TA, Aoki D, Yamagami W, Tsunoda T, Chiyoda T.: High-Throughput Drug Screening of Clear Cell Ovarian Cancer Organoids Reveals Vulnerability to Proteasome Inhibitors and Dinaciclib and Identifies AGR2 as a Therapeutic Target. Cancer Res Commun. 2025 Jun 1;5(6):1018-1033. doi: 10.1158/2767-9764.CRC-25-0024. doi: 10.1158/2767-9764.CRC-25-0024